Distinct roles of multiple isoforms of CaMKII in signaling to the nucleus.

  title={Distinct roles of multiple isoforms of CaMKII in signaling to the nucleus.},
  author={Huan Ma and Boxing Li and Richard W. Tsien},
  journal={Biochimica et biophysica acta},
  volume={1853 9},
Long-lasting synaptic changes following information acquisition are critical steps for memory. In this process, long-term potentiation (LTP) is widely considered as one of the major cellular mechanisms modifying synaptic strength. It can be classified into early phase LTP (E-LTP) and late phase LTP (L-LTP) based on its duration. Using genetically modified mice, investigators have recognized the critical role of CaMKII in E-LTP and memory. However, its function in L-LTP, which is strongly… CONTINUE READING
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