Distinct roles of complement receptor 3, Dectin-1, and sialic acids in murine macrophage interaction with Histoplasma yeast.

@article{Lin2010DistinctRO,
  title={Distinct roles of complement receptor 3, Dectin-1, and sialic acids in murine macrophage interaction with Histoplasma yeast.},
  author={J G Lin and Juin-Hua Huang and L Hung and Sheng-Yang Wu and Betty A Wu-Hsieh},
  journal={Journal of leukocyte biology},
  year={2010},
  volume={88 1},
  pages={95-106}
}
The yeast cells of dimorphic fungal pathogen Histoplasma reside primarily within the macrophages of an infected host; the interaction between the yeast and macrophage has a profound impact on host defense against the fungus. We used blocking antibodies and saccharides to identify the receptors that participate in the phagocytosis of and the cytokine response to Histoplasma. The phagocytosis and cytokine response results show that sialic acids on the macrophages were involved in the interaction… CONTINUE READING