Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation

@article{Vieira2001DistinctRO,
  title={Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation},
  author={Ot{\'i}lia V Vieira and Roberto J Botelho and Lucia E. Rameh and Saskia M. Brachmann and Tsuyoshi Matsuo and Howard W Davidson and A. Schreiber and Jonathan M. Backer and Lewis C. Cantley and Sergio Grinstein},
  journal={The Journal of Cell Biology},
  year={2001},
  volume={155},
  pages={19 - 26}
}
Phagosomes acquire their microbicidal properties by fusion with lysosomes. Products of phosphatidylinositol 3-kinase (PI 3-kinase) are required for phagosome formation, but their role in maturation is unknown. Using chimeric fluorescent proteins encoding tandem FYVE domains, we found that phosphatidylinositol 3-phosphate (PI[3]P) accumulates greatly but transiently on the phagosomal membrane. Unlike the 3'-phosphoinositides generated by class I PI 3-kinases which are evident in the nascent… CONTINUE READING
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