Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair.

@article{Xie2007DistinctRO,
  title={Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair.},
  author={Anyong Xie and Andrea J. Hartlerode and Manuel Stucki and Shobu Odate and Nadine Puget and Amy Kwok and Ganganagappa Nagaraju and Catherine Yan and Frederick W Alt and Junjie Chen and Stephen P. Jackson and Ralph Scully},
  journal={Molecular cell},
  year={2007},
  volume={28 6},
  pages={
          1045-57
        }
}
Phosphorylated histone H2AX ("gamma-H2AX") recruits MDC1, 53BP1, and BRCA1 to chromatin near a double-strand break (DSB) and facilitates efficient repair of the break. It is unclear to what extent gamma-H2AX-associated proteins act in concert and to what extent their functions within gamma-H2AX chromatin are distinct. We addressed this question by comparing the mechanisms of action of MDC1 and 53BP1 in DSB repair (DSBR). We find that MDC1 functions primarily in homologous recombination/sister… CONTINUE READING
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