Distinct roles of adenylyl cyclase VII in regulating the immune responses in mice.

@article{Duan2010DistinctRO,
  title={Distinct roles of adenylyl cyclase VII in regulating the immune responses in mice.},
  author={Biyan Duan and Richard 1. Davis and Eva L. Sadat and Julie Collins and Paul C. Sternweis and Dorothy Yuan and Lily I Jiang},
  journal={Journal of immunology},
  year={2010},
  volume={185 1},
  pages={335-44}
}
The second messenger cAMP plays a critical role in regulating immune responses. Although well known for its immunosuppressive effect, cAMP is also required for the development of optimal immune responses. Thus, the regulation of this second messenger needs to be finely tuned and well balanced in a context dependent manner. To further understand the role of cAMP synthesis in the functions of the immune system, we focus on a specific adenylyl cyclase (AC) isoform, AC VII (AC7), which is highly… CONTINUE READING
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