Distinct roles of Pcf11 zinc-binding domains in pre-mRNA 3′-end processing

@inproceedings{Guguniat2017DistinctRO,
  title={Distinct roles of Pcf11 zinc-binding domains in pre-mRNA 3′-end processing},
  author={Julia Gu{\'e}gu{\'e}niat and Adrien F. Dupin and Johan Stojko and Lionel Beaurepaire and Sarah Cianf{\'e}rani and Cameron David Mackereth and Lionel Minvielle-S{\'e}bastia and S{\'e}bastien Fribourg},
  booktitle={Nucleic acids research},
  year={2017}
}
New transcripts generated by RNA polymerase II (RNAPII) are generally processed in order to form mature mRNAs. Two key processing steps include a precise cleavage within the 3' end of the pre-mRNA, and the subsequent polymerization of adenosines to produce the poly(A) tail. In yeast, these two functions are performed by a large multi-subunit complex that includes the Cleavage Factor IA (CF IA). The four proteins Pcf11, Clp1, Rna14 and Rna15 constitute the yeast CF IA, and of these, Pcf11 is… CONTINUE READING
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