Distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating pancreas development, beta-cell function and growth.

@article{Maestro2007DistinctRO,
  title={Distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating pancreas development, beta-cell function and growth.},
  author={Miguel A Maestro and Carina Cardalda and Sylvia F. Boj and Reini F. Luco and Joan Marc Servitja and Jorge Ferrer},
  journal={Endocrine development},
  year={2007},
  volume={12},
  pages={33-45}
}
Mutations in the genes encoding transcriptional regulators HNF1beta (TCF2), HNF1alpha (TCF1), and HNF4alpha cause autosomal dominant diabetes (also known as maturity-onset diabetes of the young). Herein, we review what we have learnt during recent years concerning the functions of these regulators in the developing and adult pancreas. Mouse studies have revealed that HNF1beta is a critical regulator of a transcriptional network that controls the specification, growth, and differentiation of the… CONTINUE READING

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