Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation.

@article{Jin2011DistinctRO,
  title={Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation.},
  author={Qihuang Jin and L Yu and Lijuan Wang and Zhijing Zhang and Lawryn H. Kasper and Ji-Eun Lee and Chaochen Wang and Paul K. Brindle and Sharon Y R Dent and Kai Ge},
  journal={The EMBO journal},
  year={2011},
  volume={30 2},
  pages={249-62}
}
Histone acetyltransferases (HATs) GCN5 and PCAF (GCN5/PCAF) and CBP and p300 (CBP/p300) are transcription co-activators. However, how these two distinct families of HATs regulate gene activation remains unclear. Here, we show deletion of GCN5/PCAF in cells specifically and dramatically reduces acetylation on histone H3K9 (H3K9ac) while deletion of CBP/p300 specifically and dramatically reduces acetylations on H3K18 and H3K27 (H3K18/27ac). A ligand for nuclear receptor (NR) PPARδ induces… CONTINUE READING
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