Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila.

@article{Cabernard2005DistinctRF,
  title={Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila.},
  author={Clemens Cabernard and Markus Affolter},
  journal={Developmental cell},
  year={2005},
  volume={9 6},
  pages={831-42}
}
Branching morphogenesis is a widespread mechanism used to increase the surface area of epithelial organs. Many signaling systems steer development of branched organs, but it is still unclear which cellular processes are regulated by the different pathways. We have used the development of the air sacs of the dorsal thorax of Drosophila to study cellular events and their regulation via cell-cell signaling. We find that two receptor tyrosine kinases play important but distinct roles in air sac… CONTINUE READING