Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system.

@article{Crowley2005DistinctRF,
  title={Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system.},
  author={Steven D. Crowley and Susan B Gurley and Michael I. Oliverio and Alice K Pazmi{\~n}o and Robert Griffiths and Patrick J. Flannery and Robert F Spurney and H S Kim and Oliver Smithies and Thu H Le and Thomas M. Coffman},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 4},
  pages={1092-9}
}
Angiotensin II, acting through type 1 angiotensin (AT(1)) receptors, has potent effects that alter renal excretory mechanisms. Control of sodium excretion by the kidney has been suggested to be the critical mechanism for blood pressure regulation by the renin-angiotensin system (RAS). However, since AT(1) receptors are ubiquitously expressed, precisely dissecting their physiological actions in individual tissue compartments including the kidney with conventional pharmacological or gene… CONTINUE READING
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