Distinct roles for the essential MYST family HAT Esa1p in transcriptional silencing.

@article{Clarke2006DistinctRF,
  title={Distinct roles for the essential MYST family HAT Esa1p in transcriptional silencing.},
  author={Astrid S Clarke and Eva Samal and Lorraine Pillus},
  journal={Molecular biology of the cell},
  year={2006},
  volume={17 4},
  pages={
          1744-57
        }
}
Among acetyltransferases, the MYST family enzyme Esa1p is distinguished for its essential function and contribution to transcriptional activation and DNA double-stranded break repair. Here we report that Esa1p also plays a key role in silencing RNA polymerase II (Pol II)-transcribed genes at telomeres and within the ribosomal DNA (rDNA) of the nucleolus. These effects are mediated through Esa1p's HAT activity and correlate with changes within the nucleolus. Esa1p is enriched within the rDNA, as… CONTINUE READING

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