Distinct roles for tetraspanins CD9, CD63 and CD81 in the formation of multinucleated giant cells.

@article{Parthasarathy2009DistinctRF,
  title={Distinct roles for tetraspanins CD9, CD63 and CD81 in the formation of multinucleated giant cells.},
  author={Varadarajan Parthasarathy and Francine Martin and Adrian Higginbottom and Helen M Murray and Gregory William Moseley and Robert C Read and Gorakh Mal and Rachel S. Hulme and Peter N Monk and Lynda J. Partridge},
  journal={Immunology},
  year={2009},
  volume={127 2},
  pages={237-48}
}
Members of the tetraspanin superfamily of proteins are implicated in a variety of complex cell processes including cell fusion. However, the contribution of individual tetraspanins to these processes has proved difficult to define. Here we report the use of recombinant extracellular regions of tetraspanins to investigate the role of specific members of this family in the fusion of monocytes to form multinucleated giant cells (MGC). In contrast to their positive requirement in sperm-egg fusion… CONTINUE READING

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