Distinct roles for telethonin N-versus C-terminus in sarcomere assembly and maintenance.

@article{Sadikot2010DistinctRF,
  title={Distinct roles for telethonin N-versus C-terminus in sarcomere assembly and maintenance.},
  author={Takrima N Sadikot and Courtney R Hammond and Michael B. Ferrari},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2010},
  volume={239 4},
  pages={1124-35}
}
The N-terminus of telethonin forms a unique structure linking two titin N-termini at the Z-disc. While a specific role for the C-terminus has not been established, several studies indicate it may have a regulatory function. Using a morpholino approach in Xenopus, we show that telethonin knockdown leads to embryonic paralysis, myocyte defects, and sarcomeric disruption. These myopathic defects can be rescued by expressing full-length telethonin mRNA in morpholino background, indicating that… CONTINUE READING
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