Distinct roles for cyclooxygenases 1 and 2 in interleukin-1-induced behavioral changes.

@article{Swiergiel2002DistinctRF,
  title={Distinct roles for cyclooxygenases 1 and 2 in interleukin-1-induced behavioral changes.},
  author={Artur H. Swiergiel and Adrian J. Dunn},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2002},
  volume={302 3},
  pages={
          1031-6
        }
}
Interleukin-1 (IL-1) induces hypophagia, which can be reduced by cyclooxygenase (COX) inhibitors. Earlier studies with COX knockout (COXko) mice suggested that COX2 was more important for hypophagia than COX1. However, behavioral responses occur long before COX2 is induced. Hypophagia was assessed in mice by measuring the intake of sweetened milk in a brief period. The intake was reduced within 30 min after intraperitoneal injection of IL-1beta and was depressed for about 2 h. When milk intake… CONTINUE READING

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