Distinct roles for complement in glomerulonephritis and atherosclerosis revealed in mice with a combination of lupus and hyperlipidemia

@inproceedings{Lewis2012DistinctRF,
  title={Distinct roles for complement in glomerulonephritis and atherosclerosis revealed in mice with a combination of lupus and hyperlipidemia},
  author={Myles J Lewis and Talat Habib Malik and Liliane Fossati-Jimack and D Carassiti and H Terence Cook and Dorian O. Haskard and Marina Botto},
  booktitle={Arthritis and rheumatism},
  year={2012}
}
OBJECTIVE Although the accelerating effect of systemic lupus erythematosus (SLE) on atherosclerosis is well established, the underlying mechanisms are unknown. The aim of this study was to explore the hypothesis that lupus autoimmunity modulates the effect of hypercholesterolemia in driving arterial pathologic development. METHODS Low-density lipoprotein receptor-deficient (Ldlr(-/-) ) mice were crossed with B6.129-Sle16 (Sle16)-congenic autoimmune mice to obtain Sle16. Ldlr(-/-) mice, which… CONTINUE READING