Distinct roles for basal and induced COX-2 in podocyte injury.


Transgenic mice that overexpress cyclooxygenase-2 (COX-2) selectively in podocytes are more susceptible to glomerular injury by adriamycin and puromycin (PAN). To investigate the potential roles of COX-2 metabolites, we studied mice with selective deletion of prostanoid receptors and generated conditionally immortalized podocyte lines from mice with either… (More)
DOI: 10.1681/ASN.2009010039


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@article{Cheng2009DistinctRF, title={Distinct roles for basal and induced COX-2 in podocyte injury.}, author={Hui-fang Cheng and Xiaofeng Fan and You-fei Guan and Gilbert W. Moeckel and Roy Zent and R. Harris}, journal={Journal of the American Society of Nephrology : JASN}, year={2009}, volume={20 9}, pages={1953-62} }