Distinct roles for Xenopus Tcf/Lef genes in mediating specific responses to Wnt/beta-catenin signalling in mesoderm development.

@article{Liu2005DistinctRF,
  title={Distinct roles for Xenopus Tcf/Lef genes in mediating specific responses to Wnt/beta-catenin signalling in mesoderm development.},
  author={Fei Liu and Olaf van den Broek and Olivier Destr{\'e}e and Stefan Hoppler},
  journal={Development},
  year={2005},
  volume={132 24},
  pages={
          5375-85
        }
}
Tcf/Lef transcription factors and beta-catenin mediate canonical Wnt signalling, which plays remarkably diverse roles in embryonic development, stem cell renewal and cancer progression. To investigate the molecular mechanisms allowing for these diverse yet specific functions, we studied the several distinct roles for Wnt/beta-catenin signalling in early Xenopus development: establishing the dorsal body axis; regulating mesoderm induction; and subsequent ventrolateral patterning. Our previous… CONTINUE READING
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