Distinct roles for TBP and TBP-like factor in early embryonic gene transcription in Xenopus.

@article{Veenstra2000DistinctRF,
  title={Distinct roles for TBP and TBP-like factor in early embryonic gene transcription in Xenopus.},
  author={Glenn J. Veenstra and Daniel L Weeks and Alan P. Wolffe},
  journal={Science},
  year={2000},
  volume={290 5500},
  pages={2312-5}
}
The TATA-binding protein (TBP) is believed to function as a key component of the general transcription machinery. We tested the role of TBP during the onset of embryonic transcription by antisense oligonucleotide-mediated turnover of maternal TBP messenger RNA. Embryos without detectable TBP initiated gastrulation but died before completing gastrulation. The expression of many genes transcribed by RNA polymerase II and III was reduced; however, some genes were transcribed with an efficiency… CONTINUE READING

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