Distinct roles for Syk and ZAP-70 during early thymocyte development

  title={Distinct roles for Syk and ZAP-70 during early thymocyte development},
  author={Emil H. Palacios and Arthur Weiss},
  journal={The Journal of Experimental Medicine},
  pages={1703 - 1715}
The spleen tyrosine kinase (Syk) and zeta-associated protein of 70 kD (ZAP-70) tyrosine kinases are both expressed during early thymocyte development, but their unique thymic functions have remained obscure. No specific role for Syk during beta-selection has been established, and no role has been described for ZAP-70 before positive selection. We show that Syk and ZAP-70 provide thymocytes with unique and separable fitness advantages during early development. Syk-deficient, but not ZAP-70… CONTINUE READING


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