Distinct roles for SWR1 and INO80 chromatin remodeling complexes at chromosomal double-strand breaks.

@article{Attikum2007DistinctRF,
  title={Distinct roles for SWR1 and INO80 chromatin remodeling complexes at chromosomal double-strand breaks.},
  author={Haico van Attikum and Olivier Fritsch and Susan M. Gasser},
  journal={The EMBO journal},
  year={2007},
  volume={26 18},
  pages={4113-25}
}
INO80 and SWR1 are two closely related ATP-dependent chromatin remodeling complexes that share several subunits. Ino80 was reported to be recruited to the HO endonuclease-induced double-strand break (DSB) at the budding yeast mating-type locus, MAT. We find Swr1 similarly recruited in a manner dependent on the phosphorylation of H2A (gammaH2AX). This is not unique to cleavage at MAT; both Swr1 and Ino80 bind near an induced DSB on chromosome XV. Whereas Swr1 incorporates the histone variant H2A… CONTINUE READING
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