Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis.

@article{Munitz2008DistinctRF,
  title={Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis.},
  author={Ariel Munitz and Eric B Brandt and Melissa K. Mingler and Fred D. Finkelman and Marc E Rothenberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 20},
  pages={7240-5}
}
IL-13 and IL-4 are central T helper 2 (Th2) cytokines in the immune system and potent activators of inflammatory responses and fibrosis during Th2 inflammation. Recent studies using Il13ra1(-/-) mice have demonstrated a critical role for IL-13 receptor (IL-13R) alpha1 in allergen-induced airway responses. However, these observations require further attention especially because IL-4 can induce similar lung pathology to IL-13, independent of IL-13, and is still present in the allergic lung. Thus… CONTINUE READING
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