Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.

@article{Ricoy2014DistinctRF,
  title={Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.},
  author={Ulises Miguel Ricoy and Matthew E. Frerking},
  journal={Journal of neurophysiology},
  year={2014},
  volume={111 12},
  pages={
          2404-13
        }
}
Synaptic transmission throughout most of the CNS is steeply dependent on presynaptic calcium influx through the voltage-gated calcium channels Cav2.1-Cav2.3. In addition to triggering exocytosis, this calcium influx also recruits short-term synaptic plasticity. During the complex patterns of presynaptic activity that occur in vivo, several forms of plasticity combine to generate a synaptic output that is dynamic, in which the size of a given excitatory postsynaptic potential (EPSP) in response… CONTINUE READING

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