Distinct role of macrophages in different tumor microenvironments.

@article{Lewis2006DistinctRO,
  title={Distinct role of macrophages in different tumor microenvironments.},
  author={Claire E. Lewis and Jeffrey W. Pollard},
  journal={Cancer research},
  year={2006},
  volume={66 2},
  pages={
          605-12
        }
}
Macrophages are prominent in the stromal compartment of virtually all types of malignancy. These highly versatile cells respond to the presence of stimuli in different parts of tumors with the release of a distinct repertoire of growth factors, cytokines, chemokines, and enzymes that regulate tumor growth, angiogenesis, invasion, and/or metastasis. The distinct microenvironments where tumor-associated macrophages (TAM) act include areas of invasion where TAMs promote cancer cell motility… 
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