Distinct role of macrophages in different tumor microenvironments.

@article{Lewis2006DistinctRO,
  title={Distinct role of macrophages in different tumor microenvironments.},
  author={Claire E. Lewis and Jeffrey W. Pollard},
  journal={Cancer research},
  year={2006},
  volume={66 2},
  pages={
          605-12
        }
}
Macrophages are prominent in the stromal compartment of virtually all types of malignancy. These highly versatile cells respond to the presence of stimuli in different parts of tumors with the release of a distinct repertoire of growth factors, cytokines, chemokines, and enzymes that regulate tumor growth, angiogenesis, invasion, and/or metastasis. The distinct microenvironments where tumor-associated macrophages (TAM) act include areas of invasion where TAMs promote cancer cell motility… 

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References

SHOWING 1-10 OF 84 REFERENCES
Tumor-Associated Macrophages in Breast Cancer
  • R. Leek, A. Harris
  • Biology, Medicine
    Journal of Mammary Gland Biology and Neoplasia
  • 2004
TLDR
Recent studies have indicated that in breast cancers the protumor role of TAMs is dominant, and that TAMs may be executing a “wound healing” type of process in response to stimuli found in the tumor microenvironment, such as hypoxia.
Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues.
TLDR
The various mechanisms responsible for monocyte recruitment into tumors with those regulating the accumulation of macrophages in hypoxic/necrotic areas are compared and the relevance of these mechanisms to the development of novel cancer therapies is discussed.
Cytokine regulation of angiogenesis in breast cancer: the role of tumor‐associated macrophages
TLDR
Tumor‐associated macrophages in the stromal compartment of these tumors and/or malignant epithelial cells were seen to be a major producer cell for these cytokines, whereas tumor necrosis factor‐α receptors were expressed by leukocytes, malignant cells, and endothelial cells in tumor blood vessels.
A Paracrine Loop between Tumor Cells and Macrophages Is Required for Tumor Cell Migration in Mammary Tumors
TLDR
This work provides the first direct evidence for a synergistic interaction between macrophages and tumor cells during cell migration in vivo and indicates a mechanism for how macrophage may contribute to metastasis.
Tumour-educated macrophages promote tumour progression and metastasis
TLDR
Macrophages are educated by the tumour microenvironment, so that they adopt a trophic role that facilitates angiogenesis, matrix breakdown and tumour-cell motility — all of which are elements of the metastatic process.
Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop.
TLDR
It is shown that macrophages and tumor cells are necessary and sufficient for comigration and invasion into collagen I and that this process involves a paracrine loop.
Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma.
TLDR
Analysis of macrophage infiltration in invasive breast carcinomas indicates a role for macrophages in angiogenesis and prognosis in breast cancer and that this cell type may represent an important target for immunoinhibitory therapy in Breast cancer.
...
...