Distinct role of lymphocyte function-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytes.

@article{Anikeeva2005DistinctRO,
  title={Distinct role of lymphocyte function-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytes.},
  author={N. Anikeeva and Kristina Somersalo and T. Sims and V. K. Thomas and Michael Dustin and Y. Sykulev},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 18},
  pages={
          6437-42
        }
}
  • N. Anikeeva, Kristina Somersalo, +3 authors Y. Sykulev
  • Published 2005
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecules (ICAMs) facilitates T cell antigen receptor (TCR)-mediated killing. To dissect TCR and LFA-1 contributions, we evaluated cytolytic activity and granule release by cytotoxic T lymphocytes (CTL) as well as intracellular granule redistribution and morphology of CTL stimulated with natural TCR ligand in the presence or absence of LFA-1 engagement. Although other adhesion mechanisms, e.g., CD2-CD58… CONTINUE READING
    Functional anatomy of T cell activation and synapse formation.
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