Distinct role of lymphocyte function-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytes.

@article{Anikeeva2005DistinctRO,
  title={Distinct role of lymphocyte function-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytes.},
  author={Nadia Anikeeva and Kristina Somersalo and Tasha Nicholle Sims and Vinoo Thomas and Michael L. Dustin and Yuri Sykulev},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 18},
  pages={
          6437-42
        }
}
Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecules (ICAMs) facilitates T cell antigen receptor (TCR)-mediated killing. To dissect TCR and LFA-1 contributions, we evaluated cytolytic activity and granule release by cytotoxic T lymphocytes (CTL) as well as intracellular granule redistribution and morphology of CTL stimulated with natural TCR ligand in the presence or absence of LFA-1 engagement. Although other adhesion mechanisms, e.g., CD2-CD58… CONTINUE READING

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