Distinct role of MAPKAPK-2 in the regulation of TNF gene expression by Toll-like receptor 7 and 9 ligands.

@article{Thuraisingam2007DistinctRO,
  title={Distinct role of MAPKAPK-2 in the regulation of TNF gene expression by Toll-like receptor 7 and 9 ligands.},
  author={Thusanth Thuraisingam and Yong Zhong Xu and Jacques Moisan and Claude Lachance and James Garnon and Sergio Di Marco and Matthias Gaestel and Danuta Radzioch},
  journal={Molecular immunology},
  year={2007},
  volume={44 14},
  pages={3482-91}
}
Toll-like receptor ligands (TLRLs) produced by various pathogens activate mitogen-activated protein kinases (MAPKs). While the dependence on p38 MAPK activation for the induction of inflammatory genes by the TLR4L, lipopolysaccharide (LPS), has been well documented, the importance of the p38 pathway in gene regulation by other TLRLs is less well understood. We have focused our analysis on two TLRLs with therapeutic potential, imidazoquinoline S28463 (TLR7L) and CpG DNA (TLR9L), to explore in… CONTINUE READING

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