Distinct role of Kruppel-like factor 11 in the regulation of prostaglandin E2 biosynthesis.

@article{Buttar2010DistinctRO,
  title={Distinct role of Kruppel-like factor 11 in the regulation of prostaglandin E2 biosynthesis.},
  author={Navtej S. Buttar and Cathrine J Demars and Gwen A. Lomberk and Sumera Rizvi and Juliana Bonilla-Velez and Shalini Achra and Shahrooz Rashtak and Kenneth Kezhi Wang and Martin E Fernandez-Zapico and Raul A Urrutia},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 15},
  pages={11433-44}
}
Kruppel-like factor (KLF) proteins are emerging as key regulators of lipid metabolism, diabetes, and the biosynthesis of immunological cytokines. However, their role in the synthesis of prostaglandins, widely known biochemical mediators that act in a myriad of cell biological processes remain poorly understood. Consequently, in this study a comprehensive investigation at the cellular, biochemical, and molecular levels reveal that KLF11 inhibits prostaglandin E(2) synthesis via transcriptional… CONTINUE READING

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