Distinct retroelement classes define evolutionary breakpoints demarcating sites of evolutionary novelty

Abstract

Large-scale genome rearrangements brought about by chromosome breaks underlie numerous inherited diseases, initiate or promote many cancers and are also associated with karyotype diversification during species evolution. Recent research has shown that these breakpoints are nonrandomly distributed throughout the mammalian genome and many, termed… (More)
DOI: 10.1186/1471-2164-10-334

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