Distinct responses to hypoxia in subpopulations of distal pulmonary artery cells contribute to pulmonary vascular remodeling in emphysema

@inproceedings{Howard2012DistinctRT,
  title={Distinct responses to hypoxia in subpopulations of distal pulmonary artery cells contribute to pulmonary vascular remodeling in emphysema},
  author={Luke S Howard and Alexi Crosby and Peter Vaughan and Anastasia Sobolewski and Mark R Southwood and Martyn Foster and Edwin R Chilvers and N. W. Morrell},
  booktitle={Pulmonary circulation},
  year={2012}
}
We have shown previously that hypoxia inhibits the growth of distal human pulmonary artery smooth muscle cells (PASMC) isolated under standard normoxic conditions (PASMC(norm)). By contrast, a subpopulation of PASMC, isolated through survival selection under hypoxia was found to proliferate in response to hypoxia (PASMC(hyp)). We sought to investigate the role of hypoxia-inducible factor (HIF) in these differential responses and to assess the relationship between HIF, proliferation, apoptosis… CONTINUE READING