Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse.

  title={Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse.},
  author={Takashi Moriguchi and Hozumi Motohashi and Tomonori Hosoya and Osamu Nakajima and Satoru Takahashi and Seiichiroh Ohsako and Yasunobu Aoki and Noriko Nishimura and Chiharu Tohyama and Yoshiaki Fujii-Kuriyama and Masayuki Yamamoto},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 10},
There are large inter- and intraspecies differences in susceptibility to dioxin-induced toxicities. A critical question in risk assessment of dioxin and related compounds is whether humans are sensitive or resistant to their toxicities. The diverse responses of mammals to dioxin are strongly influenced by functional polymorphisms of the arylhydrocarbon receptor (AHR). To characterize responses mediated by the human AHR (hAHR), we generated a mouse possessing hAHR instead of mouse AHR. Responses… CONTINUE READING


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