Distinct requirements of Autophagy-related genes in programmed cell death

  title={Distinct requirements of Autophagy-related genes in programmed cell death},
  author={Tianqi Xu and Shannon Nicolson and Donna Denton and Sharad Kumar},
  journal={Cell Death and Differentiation},
Although most programmed cell death (PCD) during animal development occurs by caspase-dependent apoptosis, autophagy-dependent cell death is also important in specific contexts. In previous studies, we established that PCD of the obsolete Drosophila larval midgut tissue is dependent on autophagy and can occur in the absence of the main components of the apoptotic pathway. As autophagy is primarily a survival mechanism in response to stress such as starvation, it is currently unclear if the… CONTINUE READING
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