Distinct requirements for evoked and spontaneous release of neurotransmitter are revealed by mutations in the Drosophila gene neuronal-synaptobrevin.

@article{Deitcher1998DistinctRF,
  title={Distinct requirements for evoked and spontaneous release of neurotransmitter are revealed by mutations in the Drosophila gene neuronal-synaptobrevin.},
  author={David L Deitcher and Atsushi Ueda and Bryan A Stewart and Robert W Burgess and Yoshiaki Kidokoro and Thomas L Schwarz},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1998},
  volume={18 6},
  pages={2028-39}
}
Two modes of vesicular release of transmitter occur at a synapse: spontaneous release in the absence of a stimulus and evoked release that is triggered by Ca2+ influx. These modes often have been presumed to represent the same exocytotic apparatus functioning at different rates in different Ca2+ concentrations. To investigate the mechanism of transmitter release, we have examined the role of synaptobrevin/VAMP, a protein involved in vesicular docking and/or fusion. We generated a series of… CONTINUE READING

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Mutations in the Drosophila rop gene suggest a function in general secretion and synaptic transmission

  • SD Harrison, K Broadie, J van de Goor, G Rubin
  • Neuron
  • 1994
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