Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons.

@article{Postigo2002DistinctRF,
  title={Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons.},
  author={Antonio Postigo and Anna Maria Calella and Bernd Fritzsch and Marlies Knipper and David B. Katz and Andreas Eilers and Thomas Schimmang and Gary R Lewin and Ruediger Klein and Liliana Minichiello},
  journal={Genes & development},
  year={2002},
  volume={16 5},
  pages={633-45}
}
Signaling by brain-derived neurotrophic factor (BDNF) via the TrkB receptor, or by neurotrophin-3 (NT3) through the TrkC receptor support distinct populations of sensory neurons. The intracellular signaling pathways activated by Trk (tyrosine kinase) receptors, which in vivo promote neuronal survival and target innervation, are not well understood. Using mice with TrkB or TrkC receptors lacking the docking site for Shc adaptors (trkB(shc/shc) and trkC(shc/shc) mice), we show that TrkB and TrkC… CONTINUE READING
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