Distinct requirements for CD1d intracellular transport for development of V(alpha)14 iNKT cells.

@article{Sill2009DistinctRF,
  title={Distinct requirements for CD1d intracellular transport for development of V(alpha)14 iNKT cells.},
  author={Fenna C. M. Sill{\'e} and Mike Boxem and Dave Sprengers and Natacha Veerapen and Gurdyal S Besra and Marianne Boes},
  journal={Journal of immunology},
  year={2009},
  volume={183 3},
  pages={
          1780-8
        }
}
The positive selection of V(alpha)14 invariant (i)NKT cells in mice requires CD1d-mediated Ag presentation by CD4(+)CD8(+) thymocytes. Maturation of newly selected iNKT cells continues in the periphery and also involves CD1d expression. CD1d molecules acquire Ags for presentation in endosomal compartments, to which CD1d molecules have access through an intrinsic CD1d-encoded tyrosine motif and by association with the class II MHC chaperone, invariant chain. In this study, we report the… CONTINUE READING

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