Distinct regulation of hepatic nuclear factor 1alpha by NKX6.1 in pancreatic beta cells.

@article{Donelan2010DistinctRO,
  title={Distinct regulation of hepatic nuclear factor 1alpha by NKX6.1 in pancreatic beta cells.},
  author={William Donelan and Vijay Koya and S Li and Li-jun Yang},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 16},
  pages={12181-9}
}
Hepatic nuclear factor 1alpha (HNF1alpha) is a key regulator of development and function in pancreatic beta cells and is specifically involved in regulation of glycolysis and glucose-stimulated insulin secretion. Abnormal expression of HNF1alpha leads to development of MODY3 (maturity-onset diabetes of the young 3). We report that NK6 homeodomain 1 (NKX6.1) binds to a cis-regulatory element in the HNF1alpha promoter and is a major regulator of this gene in beta cells. We identified an NKX6.1… CONTINUE READING

References

Publications referenced by this paper.

NKX6.1 Regulates HNF1 in Beta Cells 12188 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • M. Borowiec, C. W. Liew, +7 authors S. S. Rich
  • APRIL 16,
  • 2010
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