Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

@article{Zhong2009DistinctRO,
  title={Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex},
  author={Yun Ying Zhong and Qing Wang and Xianting Li and Ying Jun Yan and Jonathan M. Backer and Brian T Chait and Nathaniel Heintz and Zhenyu Yue},
  journal={Nature Cell Biology},
  year={2009},
  volume={11},
  pages={468-476}
}
Beclin 1, a mammalian autophagy protein that has been implicated in development, tumour suppression, neurodegeneration and cell death, exists in a complex with Vps34, the class III phosphatidylinositol-3-kinase (PI(3)K) that mediates multiple vesicle-trafficking processes including endocytosis and autophagy. However, the precise role of the Beclin 1–Vps34 complex in autophagy regulation remains to be elucidated. Combining mouse genetics and biochemistry, we have identified a large in vivo… CONTINUE READING
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