Distinct regions of the periaqueductal gray are involved in the acquisition and expression of defensive responses.

@article{Oca1998DistinctRO,
  title={Distinct regions of the periaqueductal gray are involved in the acquisition and expression of defensive responses.},
  author={Beatrice M de Oca and Joseph P DeCola and Stephen Maren and Michael S Fanselow},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1998},
  volume={18 9},
  pages={3426-32}
}
In fear conditioning, a rat is placed in a distinct environment and delivered footshock. The response to the footshock itself is called an activity burst and includes running, jumping, and vocalization. The fear conditioned to the distinct environment by the footshock elicits complete immobility termed freezing. Lesions of the ventral periaqueductal gray (vPAG) strongly attenuate freezing. However, lesions of the dorsolateral periaqueductal gray (dlPAG) increase the amount of freezing seen to… CONTINUE READING
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