Distinct regional and subcellular localization of adenylyl cyclases type 1 and 8 in mouse brain.

@article{Conti2007DistinctRA,
  title={Distinct regional and subcellular localization of adenylyl cyclases type 1 and 8 in mouse brain.},
  author={Alana C. Conti and James W. Jr. Maas and Lisa M. Muglia and Bhumy A. Dav{\'e} and Sherri K. Vogt and Timothy T. Tran and E J Rayhel and Louis J. Muglia},
  journal={Neuroscience},
  year={2007},
  volume={146 2},
  pages={713-29}
}
Adenylyl cyclases (ACs) convert ATP to cAMP and therefore, subserve multiple regulatory functions in the nervous system. AC1 and AC8 are the only cyclases stimulated by calcium and calmodulin, making them uniquely poised to regulate neuronal development and neuronal processes such as learning and memory. Here, we detail the production and application of a novel antibody against mouse AC1. Along with AC8 immunohistochemistry, these data reveal distinct and partially overlapping patterns of… CONTINUE READING

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