Distinct recruitment of E2F family members to specific E2F-binding sites mediates activation and repression of the E2F1 promoter

@article{Araki2003DistinctRO,
  title={Distinct recruitment of E2F family members to specific E2F-binding sites mediates activation and repression of the E2F1 promoter},
  author={Keigo Araki and Yusuke Nakajima and Kazuhiro Eto and Masa-aki Ikeda},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={7632-7641}
}
The activity of E2F transcription factors plays a crucial role in mammalian cell-cycle progression and is controlled by physical association with the pocket proteins (pRb and its related p107 and p130). The E2F1 promoter, which contains two overlapping E2F-binding sites, is activated at the G1/S transition in an E2F-dependent manner. Mutational experiments have shown that the distal E2F-binding site on the E2F1 promoter is required for transcriptional repression in the G0 phase, whereas the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Downregulation of E2F1 during ER stress is required to induce apoptosis.

Journal of cell science • 2015
View 8 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-5 of 5 references

Nat

JM Trimarchi, Lees JA.
Rev. Mol. Cell Biol., 3, 11–20. • 2002

Mol

L Wu, EC Goodwin, +4 authors D. DiMaio
Cell. Biol., 20, 7059–7067. • 2000

J

H Rotheneder, S Geymayer, E. Haidweger
Mol. Biol., 293, 1005–1015. • 1999

Trends

J Zwicker, R. Muller
Genet., 13, 3–6. • 1997
View 1 Excerpt

Proc

A Schulze, K Zerfass, +5 authors B. Henglein
Natl. Acad. Sci. USA, 92, 11264–11268. • 1995

Similar Papers

Loading similar papers…