Distinct rat aortic smooth muscle cells differ in versican/PG-M expression.

@article{Lemire1996DistinctRA,
  title={Distinct rat aortic smooth muscle cells differ in versican/PG-M expression.},
  author={Joan M Lemire and Susan Potter-Perigo and Keith L. Hall and Thomas N Wight and Stephen M Schwartz},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1996},
  volume={16 6},
  pages={821-9}
}
Smooth muscle cells (SMCs) with distinct phenotypes are present in blood vessels, and distinct culture types appear when SMCs are maintained in vitro. For example, cultured SMCs from rat adult media grow as bipolar cells, which differ in gene expression from the predominantly cobblestone-shaped SMCs from rat pup aortas and rat neointimas that we call pi SMCs. Since proteoglycans are present at different concentrations in the normal intima and media and are elevated in atherosclerotic plaque, we… CONTINUE READING