Distinct protein targets for signals acting at the c-fos serum response element.

@article{Graham1991DistinctPT,
  title={Distinct protein targets for signals acting at the c-fos serum response element.},
  author={Rosalind Graham and Michael Gilman},
  journal={Science},
  year={1991},
  volume={251 4990},
  pages={189-92}
}
The c-fos serum response element (SRE) is a primary nuclear target for intracellular signal transduction pathways triggered by growth factors. It is the target for both protein kinase C (PKC)-dependent and -independent signals. Function of the SRE requires binding of a cellular protein, termed serum response factor (SRF). A second protein, p62TCF, recognizes the SRE-SRF complex to form a ternary complex. A mutated SRE that bound SRF but failed to form the ternary complex selectively lost… CONTINUE READING

From This Paper

Topics from this paper.
42 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

Similar Papers

Loading similar papers…