Distinct protease requirements for antigen presentation in vitro and in vivo.

Abstract

Asparagine endopeptidase (AEP) or legumain is a potentially important Ag-processing enzyme that introduces limited cleavages that trigger unfolding and class II MHC binding of different Ag substrates. AEP is necessary and sufficient for optimal processing and presentation of the tetanus toxin C fragment (TTCF) Ag in vitro, but its importance has not been… (More)
DOI: 10.4049/jimmunol.0901486

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