Distinct properties of the XY pseudoautosomal region crucial for male meiosis.

  title={Distinct properties of the XY pseudoautosomal region crucial for male meiosis.},
  author={Liisa Kauppi and Marco Barchi and Fr{\'e}d{\'e}ric Baudat and Peter J. Romanienko and Scott Keeney and Maria Jasin},
  volume={331 6019},
Meiosis requires that each chromosome find its homologous partner and undergo at least one crossover. X-Y chromosome segregation hinges on efficient crossing-over in a very small region of homology, the pseudoautosomal region (PAR). We find that mouse PAR DNA occupies unusually long chromosome axes, potentially as shorter chromatin loops, predicted to promote double-strand break (DSB) formation. Most PARs show delayed appearance of RAD51/DMC1 foci, which mark DSB ends, and all PARs undergo… CONTINUE READING

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