Distinct profiles of epigenetic evolution between colorectal cancers with and without metastasis.

Abstract

Liver metastasis is a fatal step in the progression of colorectal cancer (CRC); however, the epigenetic evolution of this process is largely unknown. To decipher the epigenetic alterations during the development of liver metastasis, the DNA methylation status of 12 genes, including 5 classical CpG island methylator phenotype (CIMP) markers, was analyzed in… (More)
DOI: 10.1016/j.ajpath.2010.12.045

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