Distinct profiles of cytotoxic granules in memory CD8 T cells correlate with function, differentiation stage, and antigen exposure.

@article{Harari2009DistinctPO,
  title={Distinct profiles of cytotoxic granules in memory CD8 T cells correlate with function, differentiation stage, and antigen exposure.},
  author={Alexandre Harari and Felicitas Bellutti Enders and Cristina Cellerai and P A Bart and Giuseppe Pantaleo},
  journal={Journal of virology},
  year={2009},
  volume={83 7},
  pages={2862-71}
}
Cytotoxic CD8 T cells exert their antiviral and antitumor activity primarily through the secretion of cytotoxic granules. Degranulation activity and cytotoxic granules (perforin plus granzymes) generally define CD8 T cells with cytotoxic function. In this study, we have investigated the expression of granzyme K (GrmK) in comparison to that of GrmA, GrmB, and perforin. The expression of the cytotoxic granules was assessed in virus-specific CD8 T cells specific to influenza virus, Epstein-Barr… CONTINUE READING
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