Distinct profiles of brain and cognitive changes in the very old with Alzheimer disease.

@article{Stricker2011DistinctPO,
  title={Distinct profiles of brain and cognitive changes in the very old with Alzheimer disease.},
  author={Nikki H. Stricker and Y Chang and Christine Fennema-Notestine and Lisa Delano-Wood and David P. Salmon and Mark W. Bondi and Anders M. Dale},
  journal={Neurology},
  year={2011},
  volume={77 8},
  pages={713-21}
}
OBJECTIVE To determine whether age-standardized brain morphometric and cognitive profiles differ in young-old (aged 60-75 years) and very-old (aged 80-91 years) patients with Alzheimer disease (AD). METHODS Using a case-control retrospective design, we compared hippocampal volume and cortical gray matter thickness in areas known to be affected by AD in 105 patients with AD and 125 healthy control (HC) participants divided into young-old and very-old subgroups. Brain morphometric and cognitive… CONTINUE READING

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