Distinct profiles of REST interactions with its target genes at different stages of neuronal development.

@article{Sun2005DistinctPO,
  title={Distinct profiles of REST interactions with its target genes at different stages of neuronal development.},
  author={Yuh-man Sun and Deborah J Greenway and Rory Johnson and Miyoko Street and Nikolai D. Belyaev and Jim Deuchars and Thomas Bee and Sandra Wilde and Noel J. Buckley},
  journal={Molecular biology of the cell},
  year={2005},
  volume={16 12},
  pages={
          5630-8
        }
}
Differentiation of pluripotent embryonic stem (ES) cells through multipotent neural stem (NS) cells into differentiated neurons is accompanied by wholesale changes in transcriptional programs. One factor that is present at all three stages and a key to neuronal differentiation is the RE1-silencing transcription factor (REST/NRSF). Here, we have used a novel chromatin immunoprecipitation-based cloning strategy (SACHI) to identify 89 REST target genes in ES cells, embryonic hippocampal NS cells… CONTINUE READING