Distinct pools of proliferating cell nuclear antigen associated to DNA replication sites interact with the p125 subunit of DNA polymerase delta or DNA ligase I.

@article{Riva2004DistinctPO,
  title={Distinct pools of proliferating cell nuclear antigen associated to DNA replication sites interact with the p125 subunit of DNA polymerase delta or DNA ligase I.},
  author={Federica Riva and Monica Savio and Ornella Cazzalini and Lucia Anna Stivala and Ivana A Scovassi and Lynne S Cox and Bernard Ducommun and Ennio Prosperi},
  journal={Experimental cell research},
  year={2004},
  volume={293 2},
  pages={357-67}
}
Proliferating cell nuclear antigen (PCNA) plays an essential role in DNA replication, repair, and cell cycle control. PCNA is a homotrimeric ring that, when encircling DNA, is not easily extractable. Consequently, the dynamics of protein-protein interactions established by PCNA at DNA replication sites is not well understood. We have used DNase I to release DNA-bound PCNA together with replication proteins including the p125-catalytic subunit of DNA polymerase delta (p125-pol delta), DNA ligase… CONTINUE READING

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