Distinct phospho-forms of cortactin differentially regulate actin polymerization and focal adhesions.

@article{Kruchten2008DistinctPO,
  title={Distinct phospho-forms of cortactin differentially regulate actin polymerization and focal adhesions.},
  author={Anne E Kruchten and Eugene W Krueger and Yu Wang and Mark A. McNiven},
  journal={American journal of physiology. Cell physiology},
  year={2008},
  volume={295 5},
  pages={C1113-22}
}
Cortactin is an actin-binding protein that is overexpressed in many cancers and is a substrate for both tyrosine and serine/threonine kinases. Tyrosine phosphorylation of cortactin has been observed to increase cell motility and invasion in vivo, although it has been reported to have both positive and negative effects on actin polymerization in vitro. In contrast, serine phosphorylation of cortactin has been shown to stimulate actin assembly in vitro. Currently, the effects of cortactin serine… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 37 references

Src phosphorylation of cortactin enhances actin assembly.

Proceedings of the National Academy of Sciences of the United States of America • 2007
View 7 Excerpts
Highly Influenced

Characterization of a new primary human pancreatic tumor line.

Cancer investigation • 1986
View 5 Excerpts
Highly Influenced

v-SRC'S hold over actin and cell adhesions

Nature Reviews Molecular Cell Biology • 2002
View 4 Excerpts
Highly Influenced

Phosphatidyl C1121 CORTACTIN PHOSPHO-FORMS AND MIGRATION AJP-Cell Physiol

AL Rozelle, LM Machesky, +7 authors HL. Yin
Curr Biol • 2008

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