Distinct phenotypes of mutant mice lacking agrin, MuSK, or rapsyn.

@article{Gautam1999DistinctPO,
  title={Distinct phenotypes of mutant mice lacking agrin, MuSK, or rapsyn.},
  author={Medha Gautam and Thomas M Dechiara and D J Glass and George D. Yancopoulos and Joshua R Sanes},
  journal={Brain research. Developmental brain research},
  year={1999},
  volume={114 2},
  pages={171-8}
}
Differentiation of the postsynaptic membrane at the neuromuscular junction requires agrin, a nerve-derived signal; MuSK, a critical component of the agrin receptor in muscle; and rapsyn, a protein that interacts with acetylcholine receptors (AChRs). We showed previously that nerve-induced AChR aggregation is dramatically impaired in knockout mice lacking agrin, MuSK, or rapsyn. However, the phenotypes of these mutants differed in several respects, suggesting that the pathway from agrin to MuSK… CONTINUE READING

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