Distinct phenotypes in zebrafish models of human startle disease☆

@inproceedings{Ganser2013DistinctPI,
  title={Distinct phenotypes in zebrafish models of human startle disease☆},
  author={Lisa Rania Ganser and Qing Yu Yan and Victoria M. James and Robert A. Kozol and Maya Topf and Robert J Harvey and Julia E. Dallman},
  booktitle={Neurobiology of Disease},
  year={2013}
}
Startle disease is an inherited neurological disorder that causes affected individuals to suffer noise- or touch-induced non-epileptic seizures, excessive muscle stiffness and neonatal apnea episodes. Mutations known to cause startle disease have been identified in glycine receptor subunit (GLRA1 and GLRB) and glycine transporter (SLC6A5) genes, which serve essential functions at glycinergic synapses. Despite the significant successes in identifying startle disease mutations, many idiopathic… CONTINUE READING
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